查看完整版本: 今日纳米(Nano Today)2007V2N3:纳米生物医学专题

今日纳米(Nano Today)2007V2N3:纳米生物医学专题

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[b]Volume 2, Issue 3, June 2007, Pages 14-21[/b]
[b]
封面上的故事:[/b]
[size=4][b]Cover story: The biomacromolecule-nanoparticle interface[/b][/size]

Monolayer-protected nanoparticles are excellent scaffolds for targeting biomacromolecules because of the possibility of engineering their surface properties. The cover story highlights recent advances in the use of nanoparticle surfaces for DNA and protein recognition.
Chang-Cheng You, Apiwat Chompoosor, and Vincent M. Rotello

[b]Abstract[/b]
The wide variety of core materials, coupled with the ability to engineer their surface properties, make monolayer-protected nanoparticles (NPs) excellent scaffolds for targeting biomacromolecules. In this review, we focus on recent advances in NP-biomacromolecule interactions, highlighting the control of biomacromolecule structure and function through engineered interactions with NP surfaces.

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Fig. 1. Applications enabled through controlled biomolecule-NP interactions.

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Fig.2 Construction of MPCs and MMPCs through citrate or Brust reduction and subsequent modification such as digestive ripening (i), Murray place-exchange reaction (ii), nucleophilic reaction (iii), and encapsulation of hydrophobic MPCs into surfactant micelles (iv).

[url=http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B82X8-4NN6NBH-J&_user=4845034&_coverDate=06%2F30%2F2007&_rdoc=16&_fmt=full&_orig=browse&_srch=doc-info%28%23toc%2333024%232007%23999979996%23651567%23FLA%23display%23Volume%29&_cdi=33024&_sort=d&_docanchor=&_ct=33&_acct=C000000593&_version=1&_urlVersion=0&_userid=4845034&md5=7294f7433957e55958b77784e4796514]:fulltext :hand :link[/url]

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[size=4][b]Features Articles[/b][/size]
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[color=Blue]Targeted nanoparticles for cancer therapy[/color][/b]

The increasing interest in using nanoparticles for cancer therapy has led to the development of smart targeted nanoparticles. These can deliver drugs at a sustained rate directly to cancer cells and may provide improved efficacy and lower toxicity.
Omid C. Farokhzad et al.

[b]Abstract [/b]
Over the past decade, there has been an increasing interest in using nanotechnology for cancer therapy. The development of smart targeted nanoparticles (NPs) that can deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. We highlight some of the promising classes of targeting molecules that are under development for the delivery of NPs. We also review the emerging technologies for the fabrication of targeted NPs using microfluidic devices.

[url=http://imageshack.us][img]http://img242.imageshack.us/img242/4388/0wchpdglbvtzzskwa19f525xl0.jpg[/img][/url]
A device for generating chemical concentration gradients for high-throughput assays. (Reprinted with permission from140. © 2004 Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc.)
[url=http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B82X8-4NN6NBH-G&_user=4845034&_coverDate=06%2F30%2F2007&_rdoc=14&_fmt=full&_orig=browse&_srch=doc-info%28%23toc%2333024%232007%23999979996%23651567%23FLA%23display%23Volume%29&_cdi=33024&_sort=d&_docanchor=&_ct=33&_acct=C000000593&_version=1&_urlVersion=0&_userid=4845034&md5=43b1695e122388bddc7f84ee91cdd203]:ftext[/url]



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[b]
[color=Blue]Magnetic nanoparticles for drug delivery[/color][/b]
Magnetic nanoparticles show potential for drug delivery by combining a magnetic core and a suitable coating for drug loading. This review looks at the problems and recent advances in their development.
Jesús Santamaría et al.

[b]Abstract[/b]
Controlled release of drugs from nanostructured functional materials, especially nanoparticles (NPs), is attracting increasing attention because of the opportunities in cancer therapy and the treatment of other ailments. The potential of magnetic NPs stems from the intrinsic properties of their magnetic cores combined with their drug loading capability and the biochemical properties that can be bestowed on them by means of a suitable coating. Here we review the problems and recent advances in the development of magnetic NPs for drug delivery, focusing particularly on the materials involved.



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[color=Blue][b]Dye-doped nanoparticles for bioanalysis[/b][/color]
[b]        Silica-based nanoparticles can be loaded with large numbers of fluorescent dye molecules for the selective tagging of a range of biomedically important targets.[/b]
[b]Weihong Tan et al.[/b]

[b]Abstract[/b]
Understanding biological processes at the molecular level with accurate quantitation needs advanced bioanalysis. In this review, we describe dye-doped silica nanoparticles (NPs), their synthesis, bioconjugation, and applications in different bioanalysis formats. Silica-based nanomaterials have been developed with optical-encoding capabilities for the selective tagging of a wide range of biomedically important targets, such as bacteria, cancer cells, and individual biomolecules. We also briefly review other closely related nanomaterials, such as quantum dots, Au NPs, and magnetic NPs. We envisage that further development of these NPs will provide a variety of advanced tools for molecular biology, genomics, proteomics, drug discovery, and diagnosis and therapy of infectious disease and cancer.
[url=http://imageshack.us][img]http://img134.imageshack.us/img134/3214/0wchpdglbvtbzskwb1a4527sh1.jpg[/img][/url]

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**** Hidden Message *****

:victory: :)

好东西，支持楼主！！！

支持:victory:

看看，生物医学好难啊！！！

回复 #1 nanosurface 的帖子

:victory: :victory: :time:

看看，生物医学好难啊！！！

thanks  a lot

这里面有好多我需要的资料，真是太感谢了！！！！！:$ :lol

thanks  a lot

很好!!!!!!!!!!!!!!!!

给我的实验又增加了一个新思路，谢谢

今日纳米(Nano Today)2007V2N3:纳米生物医学专题

好东东哦！！！！！！！！！！！

good, thank you

THANKS A L OT

xiexie,辛苦了:handshake

谢谢分享啊:victory: :victory: :victory:

对胃口,楼主好人呐
:handshake

回复 1# 的帖子

好贴！！！顶！！！支持!!!!