查看完整版本: Recent advances in iron oxide nanocrystal technology for medical imaging.

Recent advances in iron oxide nanocrystal technology for medical imaging.

[font=Arial][size=3][url=http://www.nano-biology.net/showcitationlist.php?surname=Corot&initials=C]C Corot[/url], [url=http://www.nano-biology.net/showcitationlist.php?surname=Robert&initials=P]P Robert[/url], [url=http://www.nano-biology.net/showcitationlist.php?surname=Id%C3%A9e&initials=JM]JM Idée[/url], [url=http://www.nano-biology.net/showcitationlist.php?surname=Port&initials=M]M Port[/url]lzwBx/F
[i]Guerbet Research, BP 57400, 95943 Roissy CDG, France.
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l4iA5u'N1L [/i][/size][/font][size=3]Adv Drug Deliv Rev. 2006 Sep 30;
0n+Dv$@:Ie$MK [/size][size=3][font=Verdana][url=http://dx.doi.org/10.1016/j.addr.2006.09.013]doi:10.1016/j.addr.2006.09.013[/url][/font][/size][size=3]T_8uO1v'rQ
[/size][font=Arial][size=3]Superparamagnetic iron oxide particles(SPIO and USPIO) have a variety of applications in molecular andcellular imaging. Most of the recent research has concerned cellularimaging with imaging of in vivo macrophage activity. According to theiron oxide [url=http://www.nano-biology.net/]nanoparticle[/url]composition and size which influence their biodistribution, severalclinical applications are possible: detection liver metastases,metastatic lymph nodes, inflammatory and/or degenerative diseases.USPIO are investigated as blood pool agents with T1 weighted sequencefor angiography, tumour permeability and tumour blood volume orsteady-state cerebral blood volume and vessel size index measurementsusing T2() weighted sequences. [url=http://www.stemcellscience.org/]Stem cell[/url] migration and immune cell trafficking, as well as targeted iron oxide [url=http://www.nano-biology.net/]nanoparticles[/url] for molecular imaging studies, are at the stage of proof of concept, mainly in animal models.
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Article Outline
j~r/e5G 1. Introduction
O`r~-} a1Y 2. Iron oxide nanoparticles!e,X5o2hhI.w
2.1. Chemical composition
T)A T'A'GM"D#L P 2.1.1. Outstanding problems
)tP+Df)un(}`-g"Pq 2.2. Physicochemical properties I
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2.2.1. Outstanding problems N [:F/ZD%{
2.3. In vitro macrophage uptake
m`L4N"n 2.4. Pharmacokinetics and biodistribution&LT&RQ VM i,T*v
2.5. Metabolisme'JA'kw}w
2.6. BiocompatibilityF
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3. Magnetic properties of iron oxide nanoparticles
j+L'Y'U,Ess8y 3.1. SuperparamagnetismkM3OFz2X%G&b)vy
3.2. Relaxivity of superparamagnetic materialsX7v+Vl2L J7l7TF/j
3.3. Imaging methodologies
Q&Zog2Tx 4. Iron oxide nanoparticle imaging
;ZdvK#VUv 4.1. Liver imaging
'cD'Lq.Uq 4.2. Gastrointestinal tract
]7aFH7Q^V 4.3. Metastatic lymph node imaging
e J,]5fr?6O8h 4.3.1. Outstanding problems3WIDi NSNb
4.4. T-staging of uterine neoplasmst5@.WA;h
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4.5. Macrophage imagingyClAc-mhw Q y
4.5.1. Stroke imaging
dIE^j jJ0H 4.5.2. Atherosclerosis imaging
2N,S3cgj 4.5.3. Multiple sclerosis
iL;N0b/T"S qaQ 4.5.4. Kidney disease)r\8pM*T"[P
4.5.5. Osteoarticular imaging/v#G$^r,@ M
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4.5.6. Infection
R9zF1L nZasRE 4.5.7. Acute cardiac graft rejectionb`5Nc
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4.6. Blood pool imagingQy4P|T
4.6.1. MR angiography (MRA),t{0a%u&bCiz
4.6.2. Cerebral blood volume imaging![Xa;O/? C}-D0S
4.6.3. Permeability imaging for tumour characterizationYM{{
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4.7. Brain tumourX(]q"so5n B
5. Molecular imaging:uR-T1Zq
5.1. Nanoparticle vectorizationo l$C El~W-R0~-EM
5.2. Targeted iron oxide nanoparticlesbX8T }&N(W!Q-eKA
5.3. Spatial resolution
p PV*H p0k+L9Vj 5.3.1. Outstanding problemsjq$DYB
6. Cellular labelling imagingroJ[`+BV
7. Conclusions
iG C$R2B WO A Referencesi!xt$RS2uo&j
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[/url][url=http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?itool=Abstract-def&PrId=3001&uid=17115727&db=pubmed&url=http://dx.doi.org/10.1021/ar050224s]http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?itool=Abstract-def&PrId=3001&uid=17115727&db=pubmed&url=http://dx.doi.org/10.1021/ar050224s[/url]