nanoflower 2007-10-30 05:51
Advanced materials 最新一期特刊Special Section on Bionanotechnology
[url]http://www3.interscience.wiley.com/cgi-bin/jgraphissue/116331885[/url]
[img]http://img138.imageshack.us/img138/6793/ncontent116331906a4b98exj9.jpg[/img]
Cover Picture
Cover Picture: Bionanotechnology: Enabling Biomedical Research with Nanomaterials (Adv. Mater. 20/2007) (p NA)
H. Yang, Y. Xia
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200790079
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[color=Blue]Hybrid nanoparticles with multi-functional capabilities of targeted infection, magnetic resonance (MR) imaging, and gene delivery are developed by fusing virus and MnMEIO magnetic nanoparticles. Their successful utilizations for in vitro target-specific MR imaging and enhanced green fluorescent protein (eGFP) gene delivery into CAR-positive cells are demonstrated.[/color]
Inside Front Cover: Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery (Adv. Mater. 20/2007) (p NA)
Y.-M. Huh, E.-S. Lee, J.-H. Lee, Y.-w. Jun, P.-H. Kim, C.-O. Yun, J.-H. Kim, J.-S. Suh, J. Cheon
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200790080
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Hybrid nanoparticles with multi-functional capabilities of targeted infection, magnetic resonance (MR) imaging, and gene delivery are developed by fusing virus and MnMEIO magnetic nanoparticles. Their successful utilizations for in vitro target-specific MR imaging and enhanced green fluorescent protein (eGFP) gene delivery into CAR-positive cells are demonstrated.
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Contents
Contents: Adv. Mater. 20/2007 (p 3067-3083)
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200790076
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Editorial
Bionanotechnology: Enabling Biomedical Research with Nanomaterials (p 3085-3087)
H. Yang, Y. Xia
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200702050
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Progress Reports
Tissue Engineering Based on Cell Sheet Technology (p 3089-3099)
N. Matsuda, T. Shimizu, M. Yamato, T. Okano
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701978
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Cell sheet technology utilizing of temperature-responsive culture dishes has been applied to tissue engineering. Via this technology, cell sheets can be transplanted to host tissues without using biodegradable scaffolds. This Progress Report summarizes temperature-controlled cell adhesion-detachment behavior and applications of the cell sheet technology to regeneration of cornea, periodontal ligament, bladder epithelia, oesophageal epithelia, myocardium, and liver.
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SERS as a Foundation for Nanoscale, Optically Detected Biological Labels (p 3100-3108)
W. E. Doering, M. E. Piotti, M. J. Natan, R. G. Freeman
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701984
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Au and Ag nanoparticles have optical properties that make them useful as tags in a wide variety of measurement schemes. This Progress Report discusses several different methods by which these nanoparticles can be used as surface-enhanced Raman scattering (SERS) tags for the measurement of biomolecules.
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Communications
Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery (p 3109-3112)
Y.-M. Huh, E.-S. Lee, J.-H. Lee, Y.-w. Jun, P.-H. Kim, C.-O. Yun, J.-H. Kim, J.-S. Suh, J. Cheon
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701952
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Hybrid nanoparticles with multi-functional capabilities of targeted infection, magnetic resonance (MR) imaging, and gene delivery are developed by fusing virus and MnMEIO magnetic nanoparticles. Their successful utilizations for in vitro target-specific MR imaging and enhanced green fluorescent protein (eGFP) gene delivery into CAR-positive cells are demonstrated.
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Toward the Accurate Read-out of Quantum Dot Barcodes: Design of Deconvolution Algorithms and Assessment of Fluorescence Signals in Buffer (p 3113-3118)
J. A. Lee, A. Hung, S. Mardyani, A. Rhee, J. Klostranec, Y. Mu, D. Li, W. C. W. Chan
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701955
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Signal processing methods and constraints for discerning the fluorescence signals of the QD-barcodes are explored. QD-barcodes and their corresponding fluorescence spectra (see figure) require signal processing algorithms in order to be uniquely identified. Using these algorithms, we determined the number of available barcodes for use in biological detection. We also studied the impact of chemical constraints such as buffer and pH level on the barcode and read-out design.
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Geometric Considerations of Micro- to Nanoscale Elastomeric Post Arrays to Study Cellular Traction Forces (p 3119-3123)
M. T. Yang, N. J. Sniadecki, C. S. Chen
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701956
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Micro- to nanoscale elastomeric post arrays with different post geometries were used to probe the effects of local substrate architecture on cell spreading and traction force generation in adherent cells (see figure). As post density increases, cell morphology on the post arrays increasingly resembles that of cells on continuous substrates. In addition, contractile strain energy generated by cells remained constant across substrates with different post stiffness or adhesive surface area.
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Testing Nanomaterials of Unknown Toxicity: An Example Based on Platinum Nanoparticles of Different Shapes (p 3124-3129)
A. Elder, H. Yang, R. Gwiazda, X. Teng, S. Thurston, H. He, G. Oberdörster
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701962
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Human endothelial and lung epithelial cells were exposed to nanosized Pt shapes following acellular analyses of their oxidant potential. Despite clear evidence of particle uptake by cells, the Pt nanoparticles were not found to induce cytotoxicity or oxidative stress in either cell type. Results from in vivo respiratory tract exposures suggest that the particles are retained by lung tissue and that minimal-mild lung inflammation results from exposure to the nanosized Pt particles.
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Calcium-Doped Organosilicate Nanoparticles as Gene Delivery Vehicles for Bone Cells (p 3130-3135)
S. Moudgil, J. Y. Ying
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701969
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Calcium-doped organosilicate nanoparticles for gene delivery are prepared by using a surfactant-mediated sol-gel synthesis. The enhanced uptake of these nanoparticles by osteoblast cells (see figure) makes them promising candidates for the transfection of bone cells. The complexes of Ca-SiO2 nanoparticles with DNA transfect bone cells effectively without inducing cytotoxicity in vitro.
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Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity (p 3136-3141)
L. Tong, Y. Zhao, T. B. Huff, M. N. Hansen, A. Wei, J.-X. Cheng
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701974
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Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.
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Remote Control of Bioreactions in Multicompartment Capsules (p 3142-3145)
O. Kreft, A. G. Skirtach, G. B. Sukhorukov, H. Möhwald
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701977
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Remote control over reactions in multicompartment capsules is investigated. Dual-compartment capsules were constructed by consecutive fabrication of the inner and the outer parts of CaCO3 microcapsules separated by a polyelectrolyte multilayer IR-sensitized by nanoparticle doping. Upon near-infrared laser illumination the contents of the inner capsules are mixed with the outer one. This research paves the way to a simple method for performing sophisticated bioreactions in confined volumes.
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In Situ Molecular Profiling of Breast Cancer Biomarkers with Multicolor Quantum Dots (p 3146-3151)
M. V. Yezhelyev, A. Al-Hajj, C. Morris, A. I. Marcus, T. Liu, M. Lewis, C. Cohen, P. Zrazhevskiy, J. W. Simons, A. Rogatko, S. Nie, X. Gao, R. M. O'Regan
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701983
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Quantum dot bioconjugates can be used for multiplexed and quantitative detection of tumor biomarkers in cells and tissues. This new technology should have significant impact on molecular pathology if validated with traditional techniques (such as western blotting, FISH, and IHC), and with large-scale clinical studies. In addition, it could also become the first clinical application of quantum dots.
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Intracellular Enzymatic Formation of Nanofibers Results in Hydrogelation and Regulated Cell Death (p 3152-3156)
Z. M. Yang, K. M. Xu, Z. F. Guo, Z. H. Guo, B. Xu
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701971
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Enzymatic formation of supramolecular nanofibers is demonstrated as a novel approach to induce intracellular hydrogelation and control the fate of cells or cellular functions, which can lead to a new paradigm for developing biomaterials to manage cellular artificial nanostructures (CAN), understand cellular functions beyond the molecular level, and create novel therapeutics.
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Strategies for Optimized Radiolabeling of Nanoparticles for in vivo PET Imaging (p 3157-3162)
G. Sun, J. Xu, A. Hagooly, R. Rossin, Z. Li, D. A. Moore, C. J. Hawker, M. J. Welch, K. L. Wooley
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701973
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A new strategy to construct shell crosslinked nanoparticles has been developed, containing large numbers of effective DOTAlysines per particle (> 400) for 64Cu radiolabeling. These 64Cu-complexed nanoparticles show impressive specific activities (ca. 400 Ci g-1), which suggests that they will serve as highly sensitive in vivo PET tracers at low administering doses.
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Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non-Specific Uptake by Macrophage Cells (p 3163-3166)
J. Xie, C. Xu, N. Kohler, Y. Hou, S. Sun
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701975
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A dopamine-PEG based ligand is synthesized and used to stabilize monodisperse 9 nm Fe3O4 nanoparticles in physiological conditions and against non-specific uptake by macrophage cells. Such stable nanoparticles can be used to enhance the efficiency in target-specific drug delivery and to increase the signal-to-noise ratio in magnetic resonance imaging (MRI).
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Protein-Directed Formation of Silver Nanoparticles on Carbon Nanotubes (p 3167-3170)
S. S. Bale, P. Asuri, S. S. Karajanagi, J. S. Dordick, R. S. Kane
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701981
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Studies of silver nanoparticle formation using MWNT-protein/polypeptide conjugates are reported. Our findings suggest that there is selectivity in the formation of silver nanoparticles depending on the nature of the protein. Protein-mediated mineralization is facile and can be carried out under mild conditions, thereby enabling retention of the biological activity of the protein.
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Quantifying the Performance of Protein-Resisting Surfaces at Ultra-Low Protein Coverages using Kinesin Motor Proteins as Probes (p 3171-3176)
P. Katira, A. Agarwal, T. Fischer, H.-Y. Chen, X. Jiang, J. Lahann, H. Hess
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701982
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The binding kinetics of fluorescently labeled microtubules to kinesin-coated surfaces permits the determination of the density of kinesin motor proteins adhered to the surface in the range of 0.1 - 30 m-2. This extreme sensitivity, corresponding to protein coverages of 0.004 - 1 ng cm-2, enables the characterization of advanced non-fouling coatings, such as (EG)3OH-terminated SAMs and PEGMA with applications in biomedical engineering and bionanotechnology.
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Research News
Gold Nanocages for Biomedical Applications (p 3177-3184)
S. E. Skrabalak, J. Chen, L. Au, X. Lu, X. Li, Y. Xia
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200701972
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Gold nanocages represent a novel class of biocompatible nanostructures, with potential cancer diagnostic and therapy properties intrinsic to their surface plasmon resonance (SPR). They are prepared by the galvanic replacement reaction between Ag nanocubes and HAuCl4 solution, and their SPR peak position can be precisely tuned into the near-infrared. Recent advances in the use of Au nanocages as optical contrast enhancement and photothermal therapy agents are discussed.
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Frontispiece
Frontispiece Adv. Mater. 20/2007 (p 3185)
Published Online: 17 Oct 2007
DOI: 10.1002/adma.200790077
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Progress Report
Advances in Liquid-Electrolyte and Solid-State Dye-Sensitized Solar Cells (p 3187-3200)
H. J. Snaith, L. Schmidt-Mende
Published Online: 25 Sep 2007
DOI: 10.1002/adma.200602903
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Liquid-electrolyte and solid-state dye-sensitized solar cells (DSCs) are an important candidate for future energy solutions. Recent developments in DSC research are highlighted in this Progress Report . Underlying processes, such as charge generation, transport, recombination, and charge collection are discussed. Recently developed alternative device concepts are also described, including extremely thin absorber cells, inorganic p-type hole-transporter cells, and a range of non-TiO2 mesoporous metal-oxide electrodes employed in DSCs.
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Reviews
Organic Bioelectronics (p 3201-3213)
M. Berggren, A. Richter-Dahlfors
Published Online: 25 Sep 2007
DOI: 10.1002/adma.200700419
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Bioelectronics is a technology platform that enables signal transduction between biology and traditional electronics. This technology becomes successful only if electronic signals can be translated into biological equivalences, and vice versa, at proper temporal and spatial resolution. In addition, bioelectronic devices must exhibit proper biocompatibility and biostability to function properly over time. Organic electronic devices enable several advantages as compared to inorganic electronics, in many respects, and recent progress in organic bioelectronics is described in this Review.
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Carbon Nanotubes for Electronic and Electrochemical Detection of Biomolecules (p 3214-3228)
S. N. Kim, J. F. Rusling, F. Papadimitrakopoulos
Published Online: 21 Sep 2007
DOI: 10.1002/adma.200700665
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Achieving high sensitivity and low detection limits are major challenges in biosensing. In this Review, recent advances in carbon nanotube-assisted biodetection through field effect transistor and electrochemical architectures (see figure) are summarized, along with various methodologies for signal amplification.
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