查看完整版本: 基于生物医学应用的高性能纳米磁性粒子技术

nanosurface 2006-12-31 22:23

基于生物医学应用的高性能纳米磁性粒子技术

[size=3][color=DarkGreen]       纳米粒子或者量子点已经成为纳米科技在生物医学中最有可能首先广泛应用的领域之一,有可能对病例检测和诊断,药物释放和恶性肿瘤治疗技术领域带来重大突破.本专题主要收集高性能纳米磁性粒子(单组元,多组元,核/壳层结构等)制备,表征,:nst性能和生物医学应用的文献资料及其有关进展.欢迎大家发帖支持.[/color][/size]

nanosurface 2006-12-31 22:32

[align=center][b][size=3][color=DarkGreen]Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices[/color][/size]
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[/color][/size][align=center][size=3][color=DarkGreen]Sun, Shouheng; Murray, C. B.; Weller, Dieter; Folks, Liesl; Moser, Andreas[/color][/size]
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[size=3][color=DarkGreen][b][i]Science [/i][/b](Washington, D. C.) (2000),[b] 287[/b](5460), 1989-1992 CODEN: SCIEAS; ISSN: 0036-8075. English.[/color][/size]
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Synthesis of monodisperse iron-platinum (FePt) nanoparticles by reduction of platinum acetylacetonate and decomposition of iron pentacarbonyl in the presence of oleic acid and oleyl amine stabilizers is reported. The FePt particle composition is readily controlled, and the size is tunable from 3- to 10-nm diameter with a standard deviation of <5%. These nanoparticles self-assemble into three-dimensional superlattices. Thermal annealing converts the internal particle structure from a chem. disordered fcc. phase to the chem. ordered face-centered tetragonal phase and transforms the nanoparticle superlattices into ferromagnetic nanocrystal assemblies. These assemblies are chem. and mech. robust and can support high-density magnetization reversal transitions.
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nanosurface 2006-12-31 22:42

[align=center][size=4][b]Magnetization directions of individual nanoparticles[/b][/size][/align]'~+x9M\`5h9IL4C-r
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[b]Science [/b](Washington, D. C.) (1999), [b]284[/b](5413), 470-473 CODEN: SCIEAS; ISSN: 0036-8075. English.
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The magnetization directions of individual monodomain nanoparticles as small as 5 nm in diameter are determined using the Foucault method of Lorentz microscopy. A model is developed to explain the images and diffraction patterns of samarium cobalt nanoparticles as a function of the aperture shift direction. Thermally induced changes in the magnetization direction of super-paramagnetic magnetite nanoparticles were observed but with a much slower rate than expected, due to surface anisotropy. When the time scale for magnetization reversal is much shorter than the data acquisition time, as in carbon-coated iron cobalt alloy nanoparticles, the images show an average of such thermally induced changes.
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nanosurface 2006-12-31 23:00

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t{\k.n2R6w I [/color][/size][align=center][size=4][b]Three-dimensional binary superlattices of magnetic nanocrystals and semiconductor quantum dots[/b][/size]&?OjB1nT"E;?
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&j~\;Xt2F [/color][/size][align=center][size=3]Redl, F. X.; Cho, K.-S.; Murray, C. B.; O'Brien, S.[/size]a!f4z$Pj M/?,m
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sk h{,A%A v7V$G2N b [/color][/size][align=center][size=3][b][i]Nature[/i][/b] (London, United Kingdom) (2003), 423(6943), 968-971 CODEN: NATUAS; ISSN: 0028-0836. English.[/size] q9Y rs }!M2f6bz)Z
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[&sX(r;dp!C Recent advances in strategies for synthesizing nanoparticles - such as semiconductor quantum dots, magnets and noble-metal clusters - have enabled the precise control of composition, size, shape, crystal structure, and surface chem. The distinct properties of the resulting nanometer-scale building blocks can be harnessed in assemblies with new collective properties, which can be further engineered by controlling interparticle spacing and by material processing. The study is motivated by the emerging concept of metamaterials - materials with properties arising from the controlled interaction of the different nanocrystals in an assembly. Previous multi-component nanocrystal assemblies have usually resulted in amorphous or short-range-ordered materials because of non-directional forces or insufficient mobility during assembly. Here, the authors report the self-assembly of PbSe semiconductor quantum dots and Fe2O3 magnetic nanocrystals into precisely ordered three-dimensional superlattices. The use of specific size ratios directs the assembly of the magnetic and semiconducting nanoparticles into AB13 or AB2 superlattices with potentially tunable optical and magnetic properties. This synthesis concept could ultimately enable the fine-tuning of material responses to magnetic, elec., optical and mech. stimuli.
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nanosurface 2006-12-31 23:04

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[/color][/size][align=center][size=3][color=DarkGreen][b]Facile One-Pot Synthesis of Bifunctional Heterodimers of Nanoparticles: A Conjugate of Quantum Dot and Magnetic Nanoparticles[/b][/color][/size]gS8n$T"@ v,kq
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[/color][/size][align=center][size=3][color=DarkGreen][b][i]J. Am. Chem. Soc., [/i][/b][b]126 [/b](18), 5664 -5665, 2004. 10.1021/ja0496423 S0002-7863(04)09642-8[/color][/size]d%yTA~s5nFQT
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[/color][/size][align=center][size=3][color=DarkGreen]Hongwei Gu, Rongkun Zheng, XiXiang Zhang, and Bing Xu*[/color][/size]
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[/color][/size][align=center][size=3][color=DarkGreen]Departments of Chemistry and Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong[/color][/size]FrWjS(X d4s
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[align=center][size=3][color=DarkGreen][email=chbingxu@ust.hk]chbingxu@ust.hk[/email][/color][/size]j+LK4fa
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Sequential addition of sulfur and Cd(acac)2 into the colloid solution of FePt nanoparticles (~2.5 nm) under a reductive environment generates heterodimers of CdS and FePt with sizes of ~7 nm. The heterodimers exhibit both superparamagnetism and fluorescence, indicating that the discrete properties of the individual parts of the dimers are preserved. This simple methodology may lead to the production of large quantities of various heterostructures with tailored properties on the nanoscale. '^R5aI]k
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[[i] 本帖最后由 nanosurface 于 2006-12-31 20:16 编辑 [/i]]

nanosurface 2006-12-31 23:23

[size=3]Structural Evolution in Metal Oxide/Semiconductor Colloidal Nanocrystal Heterostructures
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Chem. Mater., 18 (26), 6357 -6363, 2006. 10.1021/cm0621390 S0897-4756(06)02139-9
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Kwan-Wook Kwon, Bo Hyun Lee, and Moonsub Shim*'G O*?4DM"|

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Colloidal nanocrystal heterostructures in which two or more chemically distinct inorganic components are epitaxially fused together provide new opportunities in developing multifunctional building block materials. The ability to synthesize structurally and chemically well-defined nanocrystal heterostructures can provide novel combinations of unique properties arising at the nanometer length scale. Here, we examine the structural evolution of inverse spinel iron oxide/CdS nanocrystal heterostructures with respect to the sizes of both components. The crystal structure and the crystallinity of the initial iron oxide are first identified by a combination of X-ray diffraction and Raman scattering measurements. Studies on the size effect suggest lattice-strain-induced limitations on the achievable sizes of CdS within the heterostructures. Because of this limitation, increasing the amount of Cd/S reagents leads to multiple particle nucleation on individual iron oxide nanocrystals rather than continued growth. Larger sizes and a limited amount of the CdS component can be achieved by starting with small iron oxide nanocrystals. These results suggest that exploiting lattice strain may be a viable approach to obtaining heterostructured colloids with nanoscale precision.
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[[i] 本帖最后由 nanosurface 于 2007-01-01 00:32 编辑 [/i]]

nanoquebec 2007-01-02 21:41

[color=DarkGreen][size=3][b]Development of High Magnetization Fe3O4/Polystyrene/Silica Nanospheres viaCombined Miniemulsion/Emulsion Polymerization[/b][/size][/color]#_?6UXY{A#T
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[size=3][i]J. Am. Chem. Soc.,[/i] [b]128[/b](49), 15582-15583, 2006.10.1021/ja066165aS0002-7863(06)06165-8
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[color=DarkGreen][size=3][b]Hong Xu,[/b][b]Longlan Cui,[/b][b]Naihu Tong, and[/b][b]Hongchen Gu*[/b][/size][/color]
*ic}-V?Y*hQr [size=3][color=DarkGreen][/color][/size][color=DarkGreen][size=3][i]National Key Laboratory of Nano/Micro Fabrication Technology, Research Institute for Micro/Nano Science andTechnology, Shanghai Jiaotong University, Shanghai 200030, P.R. China[/i][/size][/color] U_"w0O7R0CQB t
[size=3][color=DarkGreen]hcgu@sjtu.edu.cn[/color][/size][color=DarkGreen][size=3][i]Received September 1, 2006 [/i][/size][/color]&J9xrzVg\.D0Q/q&q
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[color=DarkGreen][size=3][b]Abstract:[/b][/size][/color] XN,OH,xh2{li
[color=DarkGreen][size=3]Monodispersed, hydrophilic, superparamagnetic magnetic nanosphereswith a high fraction of magnetite were synthesized by combiningmodified miniemulsion/emulsion polymerization and sol-gel technique forthe first time. The surface of the nanospheres was coated by a silicalayer with controlled thickness. Transmission electron microscopyexperimental results showed well-proportioned, equal-sized,magnetite/polystyrene (Fe3O4/PS) nanospheres with a thin silica shell. Based on the TGA data, the fraction of magnetite in the Fe3O4/PSnanospheres core was estimated to be 80 wt %. Magnetizationmeasurements indicated that the superparamagnetic nature of thenanospheres had high saturation magnetization of 40 emu/g at 300 K. Theprocedures of the novel synthesis are described in detail. Alsodiscussed are the mechanisms of the novel combinedminiemulsion/emulsion polymerization processes.[/size][/color]
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JT W4Ar9R0q [color=DarkGreen][size=3][url=http://pubs.acs.org/cgi-bin/article.cgi/jacsat/2006/128/i49/pdf/ja066165a.pdf]:fulltext[/url]Fe6|r0SN
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nanoscience 2007-01-05 09:44

寻找能共同探讨磁流体在医学上应用的同仁!

我们研制成功一种磁流体,粒径在20-30纳米左右,具有非常好的磁性和水稳定性,而且我们可根据需要使其携带正电荷和负电荷或不带电荷.目前,我们正准备把它深入开发用于医学各领域的研究,我们的目标是研制出一系列的相关产品,现在我们已经能够确保相关公司提供配套开发的资金,但我们自己的研究室精力有限,不知道谁愿意和我们合作攻关.如您有兴趣,请给我发邮件.nanoscience@qq.com

nanoquebec 2007-01-17 04:04

[align=center][size=3][color=DarkGreen][b]Synthesis and Stabilization of Monodisperse Fe Nanoparticles[/b][/color][/size]8Lx&Q)E k
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[align=center][size=3][color=DarkGreen]Sheng Peng, Chao Wang, Jin Xie, and Shouheng Sun[/color][/size]x*K)g&W&u7L1d1|r
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T9qe n+c0P8F%~ [align=center][size=3][color=DarkGreen]Department of Chemistry and Division of Engineering, Brown University, Providence, Rhode Island 02912HP.}k8M!X
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:Bpb[xf,JR t [b][i]J. Am. Chem. Soc.[/i][/b], 128 (33), 10676 -10677, 2006. 10.1021/ja063969h S0002-7863(06)03969-2 #?@~,XV3y4};\
Received June 6, 2006
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Abstract:
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Monodisperse Fe nanoparticles are synthesized via a simple one-pot thermal decomposition of Fe(CO)5 in the presence of oleylamine. Controlled oxidation of the iron surface leads to crystalline Fe3O4 shell and results in dramatic increase of chemical and dispersion stability of the nanoparticles. Surface ligand exchange is readily applied to transfer the core/shell nanoparticles from hydrophobic to hydrophilic, and a stable aqueous nanoparticle dispersion in PBS is formed. The functionalized nanoparticles are suitable for biomolecule attachment and biomedical applications. [/color][/size]
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nanoquebec 2007-01-17 04:08

[size=3][color=DarkGreen][align=center][b]Magnetic nanoparticle design for medical applications[/b]
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j]+c \,n(wN S. Morneta, S. Vasseura, F. Grassetb, P. Veverkac, G. Goglioa, A. Demourguesa, J. Portiera, E. Pollertc and E. Dugueta, Corresponding Author Contact Information, E-mail The Corresponding AuthorD F#^8aQ6{
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!o3c*bg EA/h aInstitut de Chimie de la Matière Condensée de Bordeaux, UPR CNRS 9048, Université Bordeaux-1, 87 Avenue du Dr Albert Schweitzer, 33608 Pessac Cedex, France
"@&E1O8tW'D bVerres et Céramiques, UMR CNRS 6512, Université de Rennes-1, Institut de Chimie de Rennes, CS 74 205, 35042 Rennes Cedex, France_b p7Rk)th S'e
cInstitute of Physics, ASCR, 162 53 Praha 6, Czech Republic&a jhyUL5hj

'{ISz K}a,jm Abstract
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Magnetic nanoparticles have attracted attention because of their current and potential usefulness as contrast agents for magnetic resonance imaging (MRI) or colloidal mediators for cancer magnetic hyperthermia. This contribution examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint (e.g. relaxivity for MRI and specific absorption rate for hyperthermia), the factors affecting their biodistribution and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells. Then, the synthesis strategies developed in our group are presented and focused on covalent platforms capable to be tailor-derivatised by surface molecular chemistry. The opportunity of using more complex oxides than conventional magnetite for controlling the in vivo temperature is also discussed.
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[b]Article Outline[/b]
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2Kgb9@#F8E 1. Introduction
)nQ"FE?U1i W 2. MRI physical background _2wj#qC h!M
3. MFH physical backgroundsihuM+S zeA
4. Physiological background
o-c];A-y/O#g/@ 5. Magnetic nanoparticles currently used for MRI or MFH applications
/J%TjBVj 6. Our method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran;U+@*MqK"ZUI
7. Towards self-controlled heating mediators for magnetic hyperthermia
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References[/color][/size]@oiR$c1~BR#|#a
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[url=http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TX3-4J2TSCS-2&_coverDate=07%2F31%2F2006&_alid=440247516&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5579&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=05b917ddfeaa9593bc95bec1046f002c]:fulltext[/url]

lsly 2007-01-17 21:25

这篇文章很好

nanoquebec 老师,这篇文章不错。以前看过了,化学修饰的过程挺详细的。

nanoquebec 2007-01-17 22:55

回复 #11 lsly 的帖子

好文章要向大家推荐,希望见到你推荐更多的文章。自己的结果也可以介绍。谢谢!

nanost-admin 2007-01-20 02:51

纳米磁性粒子医学应用文献集锦

[size=3][color=DarkGreen][b][size=4]References 1984 & Older[/size][/b]hbE#?:yt
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8vV+{rO#i;d References 1984-1981[/b]0M_pA |l

h3S%pYXY Bartlett JM, Richardson RC, Elliott GS, Blevins WE, Janas W, Hale JR, and Silver RL. Localization of magnetic microspheres in 36 canine osteogenic sarcomas. In Davis SS, Illum L, McVie JG, and Tomlinson E (Eds.). Microspheres and drug therapy: Pharmaceutical, immunological and medical aspects. Elsevier Science Publishers, New York, 1984, pp. 413-426. uu"p'o5`'^#g

4`.Rd ab F Ishii F, Takamura A, and Noro S. Magnetic microcapsules for in vitro testing as carrier for intravascular administration of anticancer drugs: Preparation and physicochemical properties. Chem. Pharm. Bull. 32: 678-684 (1984).
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p(U k)ej5x_Go+H Kandzia J, Scholz W, Anderson MJD, and Mueller-Ruchholtz W. Magnetic albumin/protein A immunomicrospheres. I. Preparation, antibody binding capacity and chemical stability. J. Immunol. Methods. 75: 31-41 (1984).
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a} ?d3|J|f!g Liboff AR, Williams T, Strong DM, and Wistar R. Time-varying magnetic fields: Effect on DNA synthesis. Science, 223: 818-820 (1984).
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*D[4_8qK1~ |&a Odette LL, McCloskey MA, and Young SH. Ferritin conjugates as specific magnetic labels. Biophys. J. 45: 1219-1222 (1984). N,GF:a9D5N:a

M?*Rg/["h qr8bj Poznansky MJ and Juliano RL. Biological approaches to the controlled delivery of drugs: A critical review. Pharmacological Reviews, 36: 277-336 (1984).1x O \t$h~z)X'q ^

7c,Yl6d.w L_~ Robinson AL. Powerful new magnet material found. Science, 223: 920-922 (1984).XZ1C*h9u8xb)i

@q&r#[i N3k Rowbottom M and Susskind C. Electricity and medicine: History of their interaction. San Francisco Press, San Francisco, 1984.*D LTD xwk

5Md_LT:a2Php9aZX Treleaven JG, Gibson FM, Ugelstad J, Rembaum A, Philip T, Caine GD, and Kemshead JT. Removal of neuroblastoma cells from bone marrow with monoclonal antibodies conjugated to magnetic microspheres. The Lancet, January 14: 70-73 (1984).
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Uhlen M, Hornes E, and Olsvik O. Advances in biomagnetic separation. Eaton Publishing, Natick, Massachussetts, 1984.
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*W6V)tt L Ibrahim A, Couvreur P, Roland M, and Speiser P. New magnetic drug carrier. J. Pharm. Pharmacol. 35: 59-61 (1983).
hF6k:V6q-\ %?&[#r&kXQ;M5e
Kato T. Encapsulated drugs in targeted cancer therapy. In Bruck SD (Ed.). Controlled drug delivery. CRC Press, Boca Raton, FL, 1983, pp. 190-240.,u!Nr6X RO+RrAy*S
}!j ^-fa;|
Margolis LB, Namiot VA, and Kljukin LM. Magnetoliposomes: another principle of cell sorting. Biochim. Biophys. Acta, 735: 193-195 (1983).
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a Pn'N"Q Fr Ovadia H, Paterson PY, and Hale JR. Magnetic microspheres as drug carriers: Factors influencing localization at different anatomical sites in the rats. Isr. J. Med. Sci. 19: 631-637 (1983).
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'ke4C$inQ Widder KJ, Morris RM, Poore GA, Howards DP, and Senyei AE. Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: Total remission in Yoshida sarcoma-bearing rats. Eur. J. Cancer Clin. Oncol. 19: 135-139 (1983).
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Hogan PZ. The compass. Walker and Company, New York, 1982.
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Margel S, Beitler U, and Ofarim M. Polyacrolein microspheres as a new tool in cell biology. J. Cell Sci. 56: 157-175 (1982).J&_"M SM0w1D%i3`
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Sako M, Yokogawa S, Sakomoto K, Adachi S, Hirota S, Okada S, and Murao S. Transcatheter microembolization with ferropolysaccharide: A new approach to ferromagnetic embolization of tumors: Preliminary report. Invest. Radiol. 17: 573-582 (1982).A+Wl,p o-K

@/LmL6Xi%`Z Barry JW, Bookstein JJ, and Alksne JF. Ferromagnetic embolization. Radiology, 138: 341-349 (1981).
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Blakemore RP and Frankel RB. Magnetic Navigation in Bacteria. Sci. Am. 245: 58-65 (1981).
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Morimoto Y, Okumura M, Sugibayashi K, and Kato Y. Biomedical applications of magnetic fluids. II. Preparation and magnetic guidance of magnetic albumin microsphere for site specific drug delivery in vivo. J. Pharm. Dyn. 4: 624-631 (1981).t;Q-uP@
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Senyei AE, Reich SD, Gonczy C, and Widder KJ. In vivo kinetics of magnetically targeted low-dose doxorubicin. J. Pharm. Sci.: 39-41 (1981).
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5I8aC)QgO j WAixS Senyei AE and Widder KJ. Drug Targeting: Magnetically responsive albumin microspheres - a review of the system to date. Gynecol. Oncol. 12: 1-13 (1981).9d5\uD5L/W_yJXP
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Widder KJ, Morris RM, Howard DP, and Senyei AE. Tumor remission in Yoshida sarcoma-bearing rats by selective targeting of magnetic albumin microspheres containing doxorubicin. Proc. Natl. Acad. Sci. USA, 78: 579-581 (1981).
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Widder KJ, Senyei AE, Ovadia H, and Paterson PY. Specific cell binding using staphylococcal protein A magnetic microspheres. J. Pharm. Sci.: 37-39 (1981).
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,UE8m)ozQ0krlY9G [b]References from 1971 until 1980[/b]^8o:KZ9_4v0JgFf
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Gould JL. The case for magnetic sensitivity in birds and bees (such as it is). American Scientist, 68: 256-267 (1980).
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!x2Oj1G%IE\ Widder KJ, Senyei AE, and Ranney DF. Magnetically responsive microspheres and other carriers for the biophysical targeting of antitumor agents. Advances in Pharmacology and Chemotherapy, 16: 213-271 (1979).
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References 1999-1995

[size=3][color=DarkGreen][b]References 1999 [/b] y3Vnmcj

)PuZK7[ Special Issue of JMMM about Magnetic Microspheres.[/color][/size][size=3][color=DarkGreen][URL=http://imageshack.us][IMG]http://img120.imageshack.us/img120/4779/jmmmcn2.gif[/IMG][/URL][/color][/size]UB \ c^
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{&L,y0[/LOX z After every "Magnetic Carrier Meeting", we publish a book or a special issue that contains the most-up-todate research in our area. The April 1999 edition of the "Journal of Magnetism and Magnetic Materials", Volume 194 contains 38 original papers published after the 1998 meeting. Have a look at the Table of Contents.
MxT"}xA]j D W(m,P~r9{)K
Abbasov T, Herdem S, Köksal M (1999). Particle capture in axial magnetic filters with power law flow model. J Phys D: Appl Phys 32, 1097-1103.
c8`O-P:Ur
VV1\uW Atarashi T, Kim YS, Fujita T, Nakatsuka K (1999). Synthesis of ethylene-glycol based magnetic fluid using silica-coated iron particle. Journal of Magnetism and Magnetic Materials 201, 7-10.
pVW\B/A
^ w*jLc$_ Babincova M, Altanerova V, Lampert M, Altaner C, Machova E, Sramka M, Babinec P (1999). Feasibility of in vivo magnetoliposome targeting. Cellular & Molecular Biology Letters 4, 260.
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Babincova M, Leszczynska D, Sourivong P, Babinec P (1999). Picosecond laser pulses mediated drug release from magnetoliposomes. Cellular & Molecular Biology Letters 4, 625-630.
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:D"B Caho'M] Babincova M, Sourivong P, Leszczynska D, Babinec P (1999). Activation of hematoporphyrin in alternating magnetic field: Possible implications for cancer treatment. Zeitschrift für Naturforschung 54c, 993-995.$Q&p)h+w'w1yBI
(x3b&vfK#` C!Z
Measurement of local viscoelasticity and forces in living cells by magnetic tweezers. Biophysical Journal 76, 573-579.
CG-jg#X6c/b
'k;[1Y1S&F Bhatt R, Scott B, Whitney S, Bryan RN, Cloney L, Lebedev A (1999). Detection of nucleic acids by cycling probe technology on magnetic particles: high sensitivity and ease of separation. Nucleosides & Nucleotides 18, 1297-1299.
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Broomberg J, Gelinas S, Finch JA, Xu Z (1999). Review of magnetic carrier technologies for metal ion removal. Magnetic and electrical separation 9, 169-188.
8u.c\!Z_ T)k
pm2RZ-r D-H'w e4E Bryant LH, Brechbiel MW, Wu C, Bulte JWM, Herynek V, Frank JA (1999). Synthesis and relaxometry of high-generation (G=5,7,9, and 10) PAMAM dendrimer-DOTA-gadolinium chelates. Journal of Magnetic Resonance Imaging 9, 348-352.
%DyCB0^/Ls4nr2o }
$i5l:b2N&GIT Bulte JWM, Zhang SC, van Gelderen P, Herynek V, Jordan EK, Duncan ID, Frank JA (1999). Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelination. Proceedings of the National Academy of Science - USA 96, 15256-15261.7JeX@*G#fc7ic1i'~

)D7@9H ^c c'}.^%y Caldarelli-Stefano R, Vago L, Bonetto S, Nebuloni M, Costanzi G (1999). Use of magnetic beads for tissue DNA extraction and IS6110 Mycobacterium tuberculosis PCR. Journal of Clinical Pathology: Molecular Pathology 52, 158-160. s9Y/p&~zH"@H
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Carneiro AA, Baffa O, Oliveira RB (1999). Study of stomach motility using the relaxation of magnetic tracers. Physics in Medicine and Biology 44, 1691-1697.
(["z*t0k{XG#[6Z*_
@Fm,I-`|_ Caruso F, S. SA, M. G, H. M (1999). Magnetic core shell particles: Preparation of Magnetic Multilayers on Polymer Ltex Microspheres. Advanced Materials 11, 950-953.;}8T(l+R2F8T"q
t#VO1tE(Rr`;X-sv4i
Chasteen ND, Harrison PM (1999). Mineralization of ferritin: An efficient means of iron storage. Journal of Structural Biology 126, 182-194.
&a?sR WO'N I!^$gk sa&iX~)E
Consigny PM, Silverberg DA, Vitali NJ (1999). Use of endothelial cells containing superparamagnetic microspheres to improve endothelial cell delivery to arterial surfaces after angioplasty. Journal of Vascular and Interventional Radiology 10, 155-163.
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Coroiu I (1999). Relaxivities of different superparamagnetic particles for application in NMR tomography. Journal of Magnetism and Magnetic Materials 201, 449-452."E)RQ Rj/GS

1X:sk,ky1ny(`~ Creson JR, Lin AA, Li Q, Broad DF, Roberts MR, Anderson SJ (1999). The mode and duration of anti-CD28 costimulation determine resistance to infection by macrophage-tropic strains of human immunodeficiency virus type 1 in vitro. Journal of Virology 73, 9337-9347.
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yj a OIB3w de Gans BJ, Blom C, Mellema J, Philipse AP (1999). Preparation and magnetisation of a silica-magnetite inverse ferrofluid. Journal of Magnetism and Magnetic Materials 201, 11-13.
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Dobson J, St. Pierre TG, Pardoe H, Schultheiss-Grassi PP (1999). Experimental and theoretical evaluation of the interactions of biogenic magnetite with magnetic fields. In: Bersani S (ed) Electricity and magnetism in biology and medicine. Plenum, New York, 401-404.3yX8} S;e

)B_l"Kz%w*Z Dodd SJ, Williams M, Suhan JP, Williams DS, Koretsky AP, Ho C (1999). Detection of single mammalian cells by high-resolution MRI. Biophysical Journal 76, 103-109.r"|)xK f6qW
qZ(x#Gk6pI9DPCqR
Electron microscopy study of intrahepatic ultrasmall superparamagnetic iron oxide kinetics in the rat. Relation with MRI. Biology of the Cell 91, 195-208.O| P2_"e;xX r

/}W4C`c9a8E Etheredge JA, Perez SM, Taylor OR, Jander R (1999). Monarch butterflies (Danaus plexippus L.) use a magnetic compass for navigation. Proceedings of the National Academy of Science - USA 96, 13845-13846.~d {9KW*F&q{1GE!C

wL2z x4D3o Fan ZH, Mangru S, Granzow R, Heaney P, Ho W, Dong Q, Kumar R (1999). Dynamic DNA hybridization on a chip using paramagnetic beads. Analytical Chemistry 71, 4851-4859.2x-a0BDc R
!M:G&`juG-m
Fischer R, Tiemann CD, Engelhardt R, Nielsen P, Dürken M, Gabbe EE, Janka GE (1999). Assessment of iron stores in children with transfusion siderosis by biomagnetic liver susceptometry. American Journal of Hematology 60, 289-299.
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Fuh CB, Chen SY (1999). Magnetic split-flow thin fractionation of magnetically susceptible particles. Journal of Chromatography A 857, 193-204.
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$n&l5N5B.m dL Geldwerth D, Helley D, de Jong K, Sabolovic D, Sestier C, Roger J, Pons JN, Freyssinet JM, Devaux PF, Kuypers FA (1999). Detection of phosphatidylserine surface exposure on human erythrocytes using annexin-v ferrofluid. Biochemical and Biophysical Research Communications 258, 199-203.DA9^ d.w;k/u6^

&UE-?-M qS4EI Gellissen J, Axmann C, Prescher A, Bohndorf K, Lodemann KP (1999). Extra- and intracellular accumulation of ultrasmall superparamagnetic iron oxides (USPIO) in experimentally induced abscesses of the peripheral soft tissues and their effects on MRI. Magnetic Resonance Imaging 17, 557-567.NB0GO$pQt4PR
6@gICP"S&h-t+\
Hallier-Soulier S, Guillot E (1999). An immunomagnetic separation polymerase chain reaction assay for rapid and ultra-sensitive detection of Cryptosporidium parvum in drinking water. FEMS Microbiology Letters 176, 285-289.
6fsW1i7l'|_O-q 0D8|+J;OU6L9wQ f;o
Hettinger WP (1999). Catalysis challenges in Fluid Catalytic Cracking: a 49 year personal account of past and more recent contributions and some possible new and future directions for even further improvement. Catalysis Today 53, 367-284.
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Hiergeist R, Andrä W, Buske N, Hergt R, Hilger I, Richter U, Kaiser W (1999). Application of magnetite ferrofluids for hyperthermia. Journal of Magnetism and Magnetic Materials 201, 420-422.
n-Eqw x*Iw.c n0F2Q*~ aG'Bt
Johnson HE, Hutchings M, Taaning E, Rasmussen T, Knudsen LM, Hansen SW, Andersen H, Gaarsdal E, Jensen L, Nikolajsen K, Kjaesgard E, Hansen NE (1999). Selective loss of progenitor subsets following clinical CD34+ cell enrichment by magnetic field, magnetic beads or chromatography separation. Bone Marrow Transplantation 24, 1329-1336.
-q BNp-g.g:^l+FR+IW
H0V?r4p;][ Jordan A, Scholz R, Wust P, Fähling H, Felix R (1999). Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. Journal of Magnetism and Magnetic Materials 201, 413-419.'xx#yH&p@)LD@I

@3CYE5QQ/q Josephson L, Tung CH, Moore A, Weissleder R (1999). High-efficiency intracellular magnetic labeling with novel superparamagnetic- tat peptide conjugates. Bioconjugate Chemistry 10, 186-191.
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0lhj"KY-U e!b Kellar KE, Fujii DK, Gunther WHH, Briley-Saebo K, Spiller M, Koenig SH (1999). 'NC100150', a preparation of ion oxide nanoparticles ideal for positive- contrast MR angiography. Magnetic Resonance Materials in Physics, Biology and Medicine 8, 207-213.
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Kiselev MV, Gladilin AK, Melik-Nubarov NS, Sveshnikov PG, Miethe P, Levashov AV (1999). Determination of cyclosporin A in 20% ethanol by a magnetic beads-based immunofluorescence assay. Analytical Biochemistry 269, 393-398.
fJjD ]1K%^*R!T9`
$i"h8Uun0S p({ Kondo A, Fukuda H (1999). Preparation of thermosensitive magnetic microspheres and their application to bioprocesses. Colloids and Surfaces A:Physicochemical and Engineering Aspects 153, 435-438.c{i&p+Kr)N [

XY.]I e Immobilization of proteins and enzymes to fine magnetic particles. Journal of Magnetism and Magnetic Materials 201, 427-430.4Bj!P!sm5}
ru,i G f
Kopacek P, Vogt R, Jindrak L, Weise C, Safarik I (1999). Purification and characterization of the lysozyme from the gut of the soft tick Ornithodoros moubata. Insect Biochemistry & Molecular Biology 29, 989-97.
` L}k4^']y
a9Z%]+K;` s\3`h Krogh TN, Berg T, Hojrup P (1999). Protein analysis using enzymes immobilized to paramagnetic beads. Analytical Biochemistry 274, 153-162.
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BlPo E["a Kuznetsov OA, Schwuchow J, Sack FD, Hasenstein KH (1999). Curvature induced by amyloplast magnetophoresis in protonemata of the moss Ceratodon purpureus. Plant Physiology 119, 645-50.v G*Yz(N vY
k"p9`&dq
Lacava ZGM, Azevedo RB, Martins EV, Lacava LM, Freitas MLL, Garcia VAP, Rebula CA, Lemos APC, Sousa MH, Tourinho FA, Da Silva MF, Morais PC (1999). Biological effects of magnetic fluids: toxicity studies. Journal of Magnetism and Magnetic Materials 201, 431-434.9d U~2L)k$a4Od

6l'x4TSjY#{QOU Man D, Man B, Plosker H (1999). The influence of permanent magnetic field therapy on wound healing in suction lipectomy patients: a double-blind study. Plastic & Reconstructive Surgery 104, 2261-6; discussion 2267-8.
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z(B2rw3M$H Mertl M (1999). Magnetic cells: Stuff of legend? Science 283, 775.
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y_)N+X,[2{y)~ Moore PE, Laporte JD, Gonzalez S, Möller W, Heyder J, Panettieri RA, Jr., and Shore SA (1999). Glucocorticoids ablate IL-1beta-induced beta-adrenergic hyporesponsiveness in human airway smooth muscle cells. Am. J. Physiol. 277, L932-42.D6FluD0kOb4P*k

(Q#wI B:D!q#lKq#g~ Morales MP, Andres-Verges M, Veintemillas-Verdaguer S, Montero MI, Serna CJ (1999). Structural effects on the magnetic properties of ?-Fe3O3 nanoparticles. Journal of Magnetism and Magnetic Materials 203, 146-148.8JJ6Va:J~
T`9l Gc+} WS"oM
Müller R, Hiergeist R, Steinmetz H, Ayoub N, Fujisaki M, Schüppel W (1999). Barium hexaferrite ferrofluids - preparation and pysical properties. Journal of Magnetism and Magnetic Materials 201, 34-37.5c1a U4Te
} Tr}IR7} r
Murthy SN (1999). Magnetophoresis: an approach to enhance transdermal drug diffusion. Pharmazie 54, 377-9.
(ajd `*o~.T+b
J2u Xb(~T9Ua7{ Noar JH, Evans RD (1999). Rare earth magnets in orthodontics: an overview. British Journal of Orthodontics 26, 29-37.
9FM B)i B.q8D|
&Uk*hh` Paganelli G, Grana C, Chinol M, Cremonesi M, De Cicco C, De Braud F, Robertson C, Zurrida S, Casadio C, Zoboli S, Siccardi AG, Veronesi U (1999). Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin. European Journal of Nuclear Medicine 26, 348-57.
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5Y UYqzJ,?,JEO Pardoe H, Dobson J (1999). Magnetic iron biomineralization in rat brains: effects of iron loading. BioMetals 12, 77-82.:]1fL n@i
HN\S/\;Vwo1I
Partington KM, Jenkinson EJ, Anderson G (1999). A novel method of cell separation based on dual parameter immunomagnetic cell selection. Journal of Immunological Methods 223, 195-205.E'b%@$Y*v(?v
&z3o M3U/|G1d~
Peng H, Shelef LA (1999). Automated rapid screening of foods for the presence of Salmonellae. Journal of Food Protection 62, 1341-1345. S~w ~J+G
?Xk&}5?
Perrin-Cocon LA, Marche PN, Villiers CL (1999). Purification of intracellular compartments involved in antigen processing: a new method based on magnetic sorting. Biochemical Journal 338, 123-130.
`vaR1D.Wg6g.G2f\
3d|rO3e0y q Prakash NM, Brown MC, Spelman FA, Nelson JA, Read P, Heitkemper MM, Tobin RW, Pope CE (1999). Magnetic field goniometry: a new method to measure the frequency of stomach contractions. Digestive diseases and sciences 44, 1735-1740.
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Pulfer SK, Ciccotto SL, Gallo JM (1999). Distribution of small magnetic particles in brain tumor-bearing rats. Journal of Neuro-Oncology 41, 99-105.B+XU|@
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Qu S, Yang H, Ren D, Kan S, Zou G, Li D, Li M (1999). Magnetite nanoparticles prepared by precipitation from partially reduced ferric chloride aqueous solutions. Journal of Colloid and Interface Science 215, 190-192.
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nUD@S~/y0Dq7X Ramirez-Vick JE, Garcia AA, Lee J (1999). Recovery of an oligonucleotide using silver ions immobilized onto paramagnetic particles. Prep Biochem Biotechnol 28, 243-260.
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Roger J, Pons JN, Massart R, Halbreich A, Bacri JC (1999). Some biomedical applications of ferrofluids. European Physics Journal 5, 321-325.
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0G#of&RDo ~ Rosensweig RE (1999). Theory for stabilization of magnetic colloid in liquid metal. Journal of Magnetism and Magnetic Materials 201, 1-6.d}$S3Ui0CHt(g
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Safarik I, Safarikova M (1999). Use of magnetic techniques for isolation of cells. Journal of Chromatography B 722, 33-53.x;e? y H

'w.rkQZ?8XA%Px2Q Safarikova M, Safarik I (1999). Determination of proteolytic activity with magnetic dye-stained gelatin. Biotechnology Techniques 13, 621-623.5r/cv6b U4|4t _

*L^N T/C^7~'S Sauzedde F, Elaissari A, Pichot C (1999). Hydrophilic magnetic polymer latexes. 2. Encapsulation of adsorbed iron oxide nanoparticles. Colloid Polymer Sciences 277, 1041-1050.
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+SJn(BK1N U5?r Schmitz SA, Albrecht T, Wolf KJ (1999). MR angiography with superparamagnetic iron oxide: Feasibility study. Radiology 213, 603-607.,S&j)C(fXBAzc8g7]U

iwG^b,| dO Schüler D (1999). Formation of magnetosomes in magnetotactic bacteria. Journal of Molecular Microbiology and Biotechnology 1, 79-86.
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Schüler D, Frankel RB (1999). Bacterial magnetosomes: microbiology, biomineralization and biotechnological applications. Appl Microbiol Biotechnol 52, 464-473.W?$nW/`%O

&D)w(l+LO K)FB8c)@ Schüler D, Spring S, Bazylinski DA (1999). Improved technique for the isolation of magnetotactic spirilla from a freshwater sediment and their phylogenetic characterization. System Appl Microbiol 22, 466-471.
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Schultheiss-Grassi PP, Dobson J (1999). Magnetic analysis of human brain tissue. BioMetals 12, 67-72.
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Schultheiss-Grassi PP, Dobson J, Wieser HG, Kuster N (1999). Magnetic properties of the heart, spleen and liver: Evidence for biogenic magnetite in human organs. In: Bersani S (ed) Electricity and magnetism in biology and medicine. Plenum, New York, 529-532.o;Y,L r!r/d

"jb {q#T _ Schultheiss-Grassi PP, Wessiken R, Dobson J (1999). TEM investigations of biogenic magnetite extracted from the human hippocampus. Biochimica et Biophysica Acta 1426, 212-216.
t:v/AuC4y#UV 5^ E%Q @E U
Schütt W, Grüttner C, Teller J, Westphal F, Häfeli U, Paulke B, Goetz P, Finck W (1999). Biocompatible magnetic polymer carriers for in vivo radionuclide delivery. Artificial Organs 23, 98-103.
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2\v:qW|!G(p Shinkai M, Ueda K, Ohtsu S, Honda H, Kohri K, Kobayashi T (1999). Effect of functional magnetic particles on radiofrequency capacitive heating. Japanese Journal of Cancer Research 90, 699-704.
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B$S1co!Db"mn Shoge K, Mishima HK, Mukai S, Shinya M, Ishihara K, Kanno M, Sasa M (1999). Rat retinal ganglion cells culture enriched with the magnetic cell sorter. Neuroscience Letters 259, 111-114.