pharm 2007-03-13 03:34
TOP25 Hottest Articles about Pharmacutics in ScienceDirect(12-16-2007update)
上周刚收到ScienceDirect的邮件：
在当前信息爆炸的时代，订阅一份ScienceDirect TOP25 Hottest Articles不失为一个省气力的捷径。:)
TOP25 Hottest Articles - downloaded during October, November and December, 2006 - within the subject area
Pharmacology, Toxicology and Pharmaceutical Science
1. Conjugate Addition of gem-Borazirconocene Alkanes to Michael Acceptors • Article
Tetrahedron Letters, Volume 36, Issue 11, 1 March 1995, Pages 1805-1808
Pereira, S.; Srebnik, M.
2. Free radicals, metals and antioxidants in oxidative stress-induced cancer • Review article
Chemico-Biological Interactions, Volume 160, Issue 1, 1 March 2006, Pages 1-40
Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M.; Mazur, M.
3. Trends in lipase-catalyzed asymmetric access to enantiomerically pure/enriched compounds • Review article
Tetrahedron, Volume 63, Issue 8, 1 February 2007, Pages 1721-1754
Ghanem, A.
4. Toll-like receptors: From the discovery of NF@kB to new insights into transcriptional regulations in innate immunity • Article
Biochemical Pharmacology, Volume 72, Issue 9, 1 October 2006, Pages 1102-1113
Doyle, S.L.; O\'Neill, L.A.J.
5. Solubility: it's not just for physical chemists • Review article
Drug Discovery Today, Volume 11, Issue 21-22, 1 November 2006, Pages 1012-1018
Bhattachar, S.N.; Deschenes, L.A.; Wesley, J.A.
6. Bioethanol • Review article
Current Opinion in Chemical Biology, Volume 10, Issue 2, 1 April 2006, Pages 141-146
Gray, K.A.; Zhao, L.; Emptage, M.
7. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery • Review article
Pharmacology & Therapeutics, Volume 112, Issue 3, 1 December 2006, Pages 630-648
Nishiyama, N.; Kataoka, K.
8. NMR structural elucidation of photochromic quinolone photoproducts • Short communication
Tetrahedron Letters, Volume 46, Issue 37, 1 September 2005, Pages 6319-6324
Berthet, J.; Lokshin, V.; Vales, M.; Samat, A.; Vermeersch, G.; Delbaere, S.
9. Inflammation and cancer: How hot is the link? • Article
Biochemical Pharmacology, Volume 72, Issue 11, 1 November 2006, Pages 1605-1621
Aggarwal, B.B.; Shishodia, S.; Sandur, S.K.; Pandey, M.K.; Sethi, G.
10. New tools and approaches for predicting skin permeability • Review article
Drug Discovery Today, Volume 11, Issue 11-12, 1 June 2006, Pages 517-523
Degim, I.
11. Multifunctional nanocarriers • Review article
Advanced Drug Delivery Reviews, Volume 58, Issue 14, 1 December 2006, Pages 1532-1555
Torchilin, V.P.
12. Pyrrole protection • Review article
Tetrahedron, Volume 62, Issue 50, 1 December 2006, Pages 11531-11563
Jolicoeur, B.; Chapman, E.E.; Thompson, A.; Lubell, W.D.
13. RNA interference: From gene silencing to gene-specific therapeutics • Review article
Pharmacology & Therapeutics, Volume 107, Issue 2, 1 August 2005, Pages 222-239
Leung, R.K.M.; Whittaker, P.A.
14. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings • Article
Advanced Drug Delivery Reviews, Volume 46, Issue 1-3, 1 March 2001, Pages 3-26
Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J.
15. Regulation of inflammation and redox signaling by dietary polyphenols • Article
Biochemical Pharmacology, Volume 72, Issue 11, 1 November 2006, Pages 1439-1452
Rahman, I.; Biswas, S.K.; Kirkham, P.A.
16. The alternative NF-@kB pathway from biochemistry to biology: Pitfalls and promises for future drug development • Article
Biochemical Pharmacology, Volume 72, Issue 9, 1 October 2006, Pages 1161-1179
Dejardin, E.
17. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single or • Article
Clinical Pharmacology & Therapeutics, Volume 78, Issue 6, 1 December 2005, Pages 675-688
Herman, G.A.; Stevens, C.; Van Dyck, K.; Bergman, A.; Yi, B.; De Smet, M.; Snyder, K.; Hilliard, D.; Tanen, M.; Tanaka, W.; Wang, A.Q.; Zeng, W.; Musson, D.; Winchell, G.; Davies, M.J.; Ramael, S.; Go
18. Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics • Article
Trends in Pharmacological Sciences, Volume 27, Issue 11, 1 November 2006, Pages 580-586
Nebert, D.W.; Vesell, E.S.
19. Antibody production • Review article
Advanced Drug Delivery Reviews, Volume 58, Issue 5-6, 1 August 2006, Pages 671-685
Birch, J.R.; Racher, A.J.
20. The aza-Wittig reaction: an efficient tool for the construction of carbon-nitrogen double bonds • Review article
Tetrahedron, Volume 63, Issue 3, 1 January 2007, Pages 523-575
Palacios, F.; Alonso, C.; Aparicio, D.; Rubiales, G.; de los Santos, J.M.
21. Systems biology, metabolic modelling and metabolomics in drug discovery and development • Review article
Drug Discovery Today, Volume 11, Issue 23-24, 1 December 2006, Pages 1085-1092
Kell, D.B.
22. Cognitive consequences of cannabis use: Comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions • Review article
Pharmacology, Biochemistry and Behavior, Volume 81, Issue 2, 1 June 2005, Pages 319-330
Lundqvist, T.
23. GLP-1 and type 2 diabetes: physiology and new clinical advances • Review article
Current Opinion in Pharmacology, Volume 6, Issue 6, 1 December 2006, Pages 598-605
Combettes, M.M.
24. Metastatic breast cancer: an updating • Article
Biomedicine & Pharmacotherapy, Volume 60, Issue 9, 1 November 2006, Pages 548-556
Nicolini, A.; Giardino, R.; Carpi, A.; Ferrari, P.; Anselmi, L.; Colosimo, S.; Conte, M.; Fini, M.; Giavaresi, G.; Berti, P.; Miccoli, P.
25. Evolution of the stereoselective pinacol coupling reaction • Review article
Tetrahedron, Volume 62, Issue 52, 1 December 2006, Pages 12137-12158
Chatterjee, A.; Joshi, N.N.
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pharm 2007-09-07 00:49
Pharmacology, Toxicology and Pharmaceutical Science
April - June 2007
1. Alternatives to animal experimentation: The regulatory background • Review article
Toxicology and Applied Pharmacology, Volume 207, Issue 2, 1 September 2005, Pages 388-392
Garthoff, B.
2. Simultaneous Quantification of Multiple Licorice Flavonoids in Rat Plasma • Article
Journal of the American Society for Mass Spectrometry, Volume 18, Issue 4, 1 April 2007, Pages 778-782
Li, L.; Liang, S.; Du, F.; Li, C.
3. Simultaneous quantification of five major bioactive flavonoids in Rhizoma Smilacis Glabrae by high-performance liquid chromatography • Article
Journal of Pharmaceutical and Biomedical Analysis, Volume 43, Issue 5, 1 April 2007, Pages 1715-1720
Chen, L.; Yin, Y.; Yi, H.; Xu, Q.; Chen, T.
4. Stereoselective synthesis of @b-amino ketones via direct Mannich-type reaction catalyzed with silica sulfuric acid • Article
Tetrahedron, Volume 63, Issue 11, 1 March 2007, Pages 2404-2408
Wu, H.; Shen, Y.; Fan, L.y.; Wan, Y.; Zhang, P.; Chen, C.f.; Wang, W.x.
5. Free radicals, metals and antioxidants in oxidative stress-induced cancer • Review article
Chemico-Biological Interactions, Volume 160, Issue 1, 1 March 2006, Pages 1-40
Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M.; Mazur, M.
6. An anti-aging drug today: from senescence-promoting genes to anti-aging pill • Review article
Drug Discovery Today, Volume 12, Issue 5-6, 1 March 2007, Pages 218-224
Blagosklonny, M.V.
7. Inflammation and cancer: How hot is the link? • Article
Biochemical Pharmacology, Volume 72, Issue 11, 1 November 2006, Pages 1605-1621
Aggarwal, B.B.; Shishodia, S.; Sandur, S.K.; Pandey, M.K.; Sethi, G.
8. Bioethanol • Review article
Current Opinion in Chemical Biology, Volume 10, Issue 2, 1 April 2006, Pages 141-146
Gray, K.A.; Zhao, L.; Emptage, M.
9. Antimicrobial activity of the essential oil and extracts of Cordia curassavica (Boraginaceae) • Article
Journal of Ethnopharmacology, Volume 111, Issue 1, 1 April 2007, Pages 137-141
Hernandez, T.; Canales, M.; Teran, B.; Avila, O.; Duran, A.; Garcia, A.M.; Hernandez, H.; Angeles-Lopez, O.; Fernandez-Araiza, M.; Avila, G.
10. Multifunctional nanocarriers • Review article
Advanced Drug Delivery Reviews, Volume 58, Issue 14, 1 December 2006, Pages 1532-1555
Torchilin, V.P.
11. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery • Review article
Drug Discovery Today, 1 May 2007, Pages 373-381
Zhang, S.; Zhang, Z.Y.
12. Insights for the development of specific kinase inhibitors by targeted structural genomics • Review article
Drug Discovery Today, 1 May 2007, Pages 365-372
Fedorov, O.; Sundstrom, M.; Marsden, B.; Knapp, S.
13. NMDA receptor subunits: function and pharmacology • Review article
Current Opinion in Pharmacology, Volume 7, Issue 1, 1 February 2007, Pages 39-47
Paoletti, P.; Neyton, J.
14. Circadian genes, rhythms and the biology of mood disorders • Review article
Pharmacology & Therapeutics, Volume 114, Issue 2, 1 May 2007, Pages 222-232
McClung, C.A.
15. Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles • Review article
Tetrahedron, 1 May 2007, Pages 4571-4624
Bellina, F.; Cauteruccio, S.; Rossi, R.
16. Polysaccharide hydrogels for modified release formulations • Review article
Journal of Controlled Release, Volume 119, Issue 1, 1 May 2007, Pages 5-24
Coviello, T.; Matricardi, P.; Marianecci, C.; Alhaique, F.
17. shRNA and siRNA delivery to the brain • Review article
Advanced Drug Delivery Reviews
Pardridge, W.M.
18. Simultaneous determination of vitexin-4''-O-glucoside and vitexin-2''-O-rhamnoside from hawthorn leaves flavonoids in rat plasma by HPLC method and its application to pharmacokinetic studies • Short communication
Journal of Pharmaceutical and Biomedical Analysis, Volume 44, Issue 1, 1 May 2007, Pages 243-249
Ma, G.; Jiang, X.H.; Chen, Z.; Ren, J.; Li, C.R.; Liu, T.M.
19. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings • Article
Advanced Drug Delivery Reviews, Volume 46, Issue 1-3, 1 March 2001, Pages 3-26
Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J.
20. Stereoselective synthesis of tarchonanthuslactone via the Prins cyclisation • Article
Tetrahedron, Volume 63, Issue 12, 1 March 2007, Pages 2689-2694
Yadav, J.S.; Kumar, N.N.; Reddy, M.S.; Prasad, A.R.
21. Reactivity of ionic liquids • Review article
Tetrahedron, Volume 63, Issue 11, 1 March 2007, Pages 2363-2389
Chowdhury, S.; Mohan, R.S.; Scott, J.L.
22. Matrix metalloproteinases (MMPs): Chemical-biological functions and (Q)SARs • Review article
Bioorganic & Medicinal Chemistry, Volume 15, Issue 6, 1 March 2007, Pages 2223-2268
Verma, R.P.; Hansch, C.
23. The present and future of nanotechnology in human health care • Article
Nanomedicine: Nanotechnology, Biology and Medicine, Volume 3, Issue 1, 1 March 2007, Pages 20-31
Sahoo, S.K.; Parveen, S.; Panda, J.J.
24. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer • Review article
Journal of Ethnopharmacology, Volume 109, Issue 2, 1 January 2007, Pages 177-206
Lansky, E.P.; Newman, R.A.
25. Translational research in the pharmaceutical industry: from theory to reality • Review article
Drug Discovery Today, 1 May 2007, Pages 419-425
Sultana, S.R.; Roblin, D.; O\'Connell, D.
pharm 2007-12-18 00:24
Pharmacology, Toxicology and Pharmaceutical Science
July - September 2007
1. 3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis • Article
Bioorganic & Medicinal Chemistry, Volume 13, Issue 8, 1 April 2005, Pages 2773-2782
Bhongade, B.A.; Gouripur, V.V.; Gadad, A.K.
2. Predicting anti-HIV activity of PETT derivatives: CoMFA approach • Short communication
Bioorganic & Medicinal Chemistry Letters, Volume 17, Issue 8, 1 April 2007, Pages 2197-2202
Ravichandran, V.; Agrawal, R.K.
3. Selectivity criterion for pyrazolo[3,4-b]pyrid[az]ine derivatives as GSK-3 inhibitors: CoMFA and molecular docking studies • Article
European Journal of Medicinal Chemistry
Patel, D.S.; Bharatam, P.V.
4. The use of a new hydrophilic polymer, Kollicoat IR^(R), in the formulation of solid dispersions of Itraconazole • Article
European Journal of Pharmaceutical Sciences, Volume 30, Issue 3-4, 1 March 2007, Pages 288-294
Janssens, S.; de Armas, H.N.; Remon, J.P.; Van den Mooter, G.
5. Three-dimensional QSAR of HPPD inhibitors, PSA inhibitors, and anxiolytic agents: Effect of tautomerism on the CoMFA models • Article
Journal of Molecular Graphics and Modelling
Zou, J.W.; Luo, C.C.; Zhang, H.X.; Liu, H.C.; Jiang, Y.J.; Yu, Q.S.
6. Asymmetric organocatalysis • Review article
Tetrahedron
Pellissier, H.
7. Conformational complexity of G-protein-coupled receptors • Review article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 397-406
Kobilka, B.K.; Deupi, X.
8. Free radicals, metals and antioxidants in oxidative stress-induced cancer • Review article
Chemico-Biological Interactions, Volume 160, Issue 1, 1 March 2006, Pages 1-40
Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M.; Mazur, M.
9. Toll-like receptors in inflammation, infection and cancer • Review article
International Immunopharmacology, Volume 7, Issue 10, 1 October 2007, Pages 1271-1285
Chen, K.; Huang, J.; Gong, W.; Iribarren, P.; Dunlop, N.M.; Wang, J.M.
10. Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy • Article
Drug Resistance Updates, Volume 10, Issue 1-2, 1 February 2007, Pages 13-29
Maddika, S.; Ande, S.R.; Panigrahi, S.; Paranjothy, T.; Weglarczyk, K.; Zuse, A.; Eshraghi, M.; Manda, K.D.; Wiechec, E.; Los, M.
11. Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? • Article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 366-373
Schwartz, T.W.; Holst, B.
12. New reaction and new catalyst-a personal perspective • Article
Tetrahedron, Volume 63, Issue 35, 1 August 2007, Pages 8377-8412
Yamamoto^*, H.
13. Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics • Review article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 431-437
Gilchrist, A.
14. Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering • Review article
Advanced Drug Delivery Reviews, Volume 59, Issue 4-5, 1 May 2007, Pages 234-248
Habraken, W.J.E.M.; Wolke, J.G.C.; Jansen, J.A.
15. A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding • Review article
Drug Discovery Today, Volume 12, Issue 15-16, 1 August 2007, Pages 622-633
Bogoyevitch, M.A.; Fairlie, D.P.
16. @b-Arrestin-biased ligands at seven-transmembrane receptors • Review article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 416-422
Violin, J.D.; Lefkowitz, R.J.
17. Developing early formulations: Practice and perspective • Review article
International Journal of Pharmaceutics, Volume 341, Issue 1-2, 1 August 2007, Pages 1-19
Li, P.; Zhao, L.
18. GPCR functional selectivity has therapeutic impact • Article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 390-396
Mailman, R.B.
19. The evasive nature of drug efficacy: implications for drug discovery • Review article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 423-430
Galandrin, S.; Oligny-Longpre, G.; Bouvier, M.
20. Cyclodextrins as pharmaceutical solubilizers • Review article
Advanced Drug Delivery Reviews, 1 July 2007, Pages 645-666
Brewster, M.E.; Loftsson, T.
21. Synthesis and SAR of p38@a MAP kinase inhibitors based on heterobicyclic scaffolds • Short communication
Bioorganic & Medicinal Chemistry Letters, 1 September 2007, Pages 5019-5024
Murali Dhar, T.G.; Wrobleski, S.T.; Lin, S.; Furch, J.A.; Nirschl, D.S.; Fan, Y.; Todderud, G.; Pitt, S.; Doweyko, A.M.; Sack, J.S.; Mathur, A.; McKinnon, M.; Barrish, J.C.; Dodd, J.H.; Schieven, G.L.
22. Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology • Article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 382-389
Leach, K.; Sexton, P.M.; Christopoulos, A.
23. Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates • Article
Trends in Pharmacological Sciences, Volume 28, Issue 8, 1 August 2007, Pages 374-381
Baker, J.G.; Hill, S.J.
24. Bioethanol • Review article
Current Opinion in Chemical Biology, Volume 10, Issue 2, 1 April 2006, Pages 141-146
Gray, K.A.; Zhao, L.; Emptage, M.
25. RNAi therapeutics: Principles, prospects and challenges • Review article
Advanced Drug Delivery Reviews
Aagaard, L.; Rossi, J.J.
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