nanosurface 2007-06-06 23:59
2006纳米科技研究的领军人物：MIT的Angela Belcher
[color=Blue]【NanoST 编者注】科学美国人杂志评出的2006年杰出科学及之一就是MIT的纳米科技专家[/color][b]Angela Belcher[/b][color=Blue] 教授。让我们一起来关注一下这位教授的足迹。[/color]
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[b]Angela Belcher教授的玉照
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个人简介：`lH2r4@
[/b][color=Green]Dr. Angela Belcher is a materials chemist with expertise in the fields of biomaterials, biomolecular materials, organic-inorganic interfaces and solid state chemistry. The focus of Dr. Belcher’s research is understanding and using the process by which Nature makes materials in order to design novel hybrid organic-inorganic electronic and magnetic materials on new length scales. Her research is very interdisciplinary in nature and brings together he fields of inorganic chemistry, materials chemistry, biochemistry, molecular biology and electrical engineering. Among her awards are the Presidential Early Career Award in Science and Engineering (2000), and the Du Pont Young Investigators Award (1999). Her research was mentioned in a July 2001 Forbes magazine cover story on nanotechnology.:f)hm b5[6y'v
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[/color]Professor Belcher will lead the Institute for Collaborative Biotechnologies; the [url=http://web.mit.edu/newsoffice/nr/2003/icb.html]MIT News Office[/url], the November 2003 issue of [url=http://www.materialstoday.com/pdfs_6_11/policy.pdf][i]Materials Today[/i][/url], and the [url=http://www.technologyreview.com/]February 2004 [i]Technology Review[/i][/url] have further details. [url=http://web.mit.edu/newsoffice/nr/2002/women.html][i]Tech Talk[/i][/url] reported on seven MIT women who have been named "Top Scientists" in 2002; Professor Belcher has been named one of Popular Science magazine's "PopSci Brilliant 10." Her research was recently mentioned in [url=http://www.technologyinsider.com/][i]Technology Insider[/i][/url], [url=http://ilp.mit.edu/ilp/Members/MITReport/MITR_Index.html]The MIT Report[/url], [url=http://www.technologyreview.com/][i]Technology Review[/i][/url], and the February 12, 2004 issue of [i]The New York Times[/i].
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[b]RESEARCH LEADER OF THE YEAR[/b]
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[b]Angela Belcher[/b]
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[i]Massachusetts Institute of Technology[/i]
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[i]This eclectic investigator draws inspiration from nature's genius for building things at the nanoscalefi-? UYO*im
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[/i]The crux of nanotechnology is the problem of self-assembly, gettinguncooperative atoms to link and align themselves up in precise ways. Weknow it can be done, of course: life persists by turning molecules intocomplex biological machinery. How fitting, then, that one of today'smost creative materials scientists, Angela Belcher of the MassachusettsInstitute of Technology, has turned to nature for assistance. Belcherhas pioneered the use of custom-evolved viruses in synthesizingnano-scale wires and arrays, fusing different research disciplines intosomething uniquely her own.
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Belcher got her start with abalone, a cousin to oysters. Themollusk had evolved a system for accreting a hard shell from calciumcarbonate, the same material of which chalk is made. As a graduatestudent at the University of California, Santa Barbara, Belcherelucidated the molecular assembly scheme abalone employed to grow itsshell and tweaked a key protein to accelerate the growth process. Soonhead of her own lab, she was standing on her desk one day, ponderingthe periodic table of elements and wondering how far she could pushnature's ability to manipulate inorganic elements.Abalone had learned to control calcium. She decided that she wouldteach nature to work with the rest of the list. "The aim is to work ourway through the whole periodic table and be able to design materials ofall kinds in a controlled way. My biggest goal is to have a DNAsequence that can code for the synthesis of any useful material," shetold MIT's [i]Technology Review[/i]. ~ ?2qdD p
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She started with the DNA sequence of the M13 bacteriophage, a long,tubular virus six nanometers wide. She engineered a version of thevirus that latched onto quantum dots, nanometer-size specks ofsemiconductor with desirable electromagnetic properties, by repeatedlyselecting the virus particles best able to cling to the dots. In amatter of months she evolved a virus that held a chunk of materialsteadfastly on one end, like a ball and chain. By dissolving the virusparticles she could make them align themselves thickly like hairs allcapped with quantum dots. The viruses are packed so densely that theyessentially form thin films, which can be stacked closer together thanother means can quickly achieve. j&G'h*b!m&b \6F
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More recently she customized M13 to stud its length with metalparticles such as cobalt oxide and gold, yielding metal nanowires thatcould be used in high energy-density electrodes. By growing the viruson a film she could make a thin, flexible metal oxide coating suitablefor storing energy chemically. Those could be incorporated, forexample, into thin-film batteries that coat the surface of a device orfit into nonstandard shapes. Belcher co-founded Cambrios Technologiesin Mountain View, Calif., to turn some of her demonstrations intocommercial devices such as solar cells and light-emitting diodes. Shehas her sights on other organisms too and has started working withyeast in order to engineer more complex nanostructures.f
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To meet her goals, Belcher has committed herself to adding anew field to her repertoire every five years. Starting as a biochemist,she has incorporated materials chemistry, electrical engineering andmolecular biology, in effect starting from scratch each time. Like theabalone's shell, this bit-by-bit accretion yields solid results.
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她的研究小组主页在这里{E-\'t X\+[8y0e
[url=http://belcher10.mit.edu/]http://belcher10.mit.edu/[/url]
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部分文章
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Chiang, C. Y., Mello, C.M., Gu,J., Silva, E.C.C.M., Van Vliet, K.J., and Belcher, A. M. “WeavingGenetically Engineered Functionality into Mechanically Robust VirusFibers.” Adv. Mater., 19, 826–832, 2007. (cover)
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Khalil,A.S., Ferrer, J.M., Brau, R.R., Kottmann, S.T., Noren, C.J., Lang,M.J., and Belcher, A.M. “Single M13 bacteriophage tethering andstretching.” PNAS, 104 (12), 4892–4897, 2007. (cover)
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Bhaviripudi,S., Mile, E., Steiner III, S.A., Zare, A.T., Dresselhaus, M.S.,Belcher, A.M. and Kong, J. “CVD Synthesis of Single-Walled CarbonNanotubes from Gold Nanoparticle Catalysts.” JACS, 129, 1516-1517,2007.
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Krauland, E. M., Peelle, B. R., Wittrup, K. D., andBelcher, A. M . “Peptide tags for enhanced cellular and proteinadhesion to single-crystalline sapphire.” Accepted, Biotechnology andBioengineering, 2006.
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Bhaviripudi, S., Reina, A., Qi, J.,Kong, J., and Belcher, A. M. “Block-copolymer assisted synthesis ofarrays of metal nanoparticles and their catalytic activities for thegrowth of SWNTs.” Nanotechnology, 17, 5080-5086, 2006.3]9@ n1h~
Nam,K. T., Kim, D. W., Yoo, P. J., Chiang, C. Y., Meethong, N., Hammond, P.T., Chang, Y. M., Belcher, A. M. “Virus Enabled Synthesis and Assemblyof Nanowires for Lithium Ion Battery Electrodes,” Science, [u]312[/u], 885-888, 2006.
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Yoo,P. J., Nam, K., Qi, J., Lee, S. K., Park, J., Belcher, A. M., Hammond,P. T., “Spontaneous assembly of viruses on multilayered polymersurfaces,” Nature Materials, [u]5[/u], 234-240, 2006. W fu Lj;k
Sinensky, A., Belcher, A. M., “Biomolecular Recognition of Crystal Defects: A Diffuse Selection Approach,” Advanced Materials, [u]18[/u], 991-996, 2006.
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Lee,S. K., Yun, D. S., Belcher, A. M., “Cobalt ion Mediated Self-Assemblyof Genetically Engineered Bacteriophage for Biomimetic Co-Pt HybridMaterial,” Biomacromolecules, [u]7[/u], 14-17, 2005.je L&S m
Huang,Y., Chiang, C. Y., Lee, S. K., Gao, Y., Hu, E., De Yoreo, J., Belcher,A. M., “Programmable Assembly of Nanoarchitectures Using GeneticallyEngineered Viruses,” Nano Letters, [u]5,[/u] 7, 1429-1434, 2005.
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Klem,M.T., Willits, D., Solis, D.J., Belcher, A.M., Young, M. Douglas, T.,“Bio-inspired synthesis of protein encapsulated CoPt nanoparticles”Advanced Materials, [u]15[/u], 9, 1489-1494, 2005.
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Sanghvi,Archit B.; Miller, Kiley P.-H.; Belcher, Angela M.; Schmidt, ChristineE. Biomaterials functionalization using a novel peptide thatselectively binds to a conducting polymer. Nature Materials (2005),4(6), 496-502. }y,I
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Peelle, B. R., Krauland, E. M., Wittrup, K.D., Belcher, A. M.,“Design criteria for engineering inorganic-materialspecific peptides,” Langmuir, 21, 15, 6929-6933, 2005.
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Peelle,B., Krauland, E., Wittrup, D. and Belcher, A.M, “Probing the interfacebetween biomolecules and inorganic materials using yeast surfacedisplay and genetic engineering,” Acta Biomaterialia, 1, 145-154, 2004.
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Sweeney,Rozamond Y.; Mao, Chuanbin; Gao, Xiaoxia; Burt, Justin L.; Belcher,Angela M.; Georgiou, George; Iverson, Brent L. Bacterial Biosynthesisof Cadmium Sulfide Nanocrystals. Chemistry & Biology (2004),11(11), 1553-1559.
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Pavel, Ioana; Belcher, Angela; Browning,Karen S. A method for coupled transcription and aminoacylation ofcysteinyl-tRNA. Analytical Biochemistry (2004), 335(2), 192-195.
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Jaffar,Saeeda; Nam, Ki Tae; Khademhosseini, Ali; Xing, Jia; Langer, Robert S.;Belcher, Angela M.. Layer-by-layer surface modification and patternedelectrostatic deposition of quantum dots. Nano Letters (2004), 4(8),1421-1425.Q fpe`)z
Reiss, Brian D.; Mao, Chuanbin; Solis, Daniel J.;Ryan, Katherine S.; Thomson, Thomas; Belcher, Angela M.. BiologicalRoutes to Metal Alloy Ferromagnetic Nanostructures. Nano Letters(2004), 4(6), 1127-1132.
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Sanghvi, Archit B.; Miller, KileyP.-H.; Belcher, Angela M.; Schmidt, Christine E. Fabricating novelbiomimetic polymers using combinatorial peptide screening technologies.Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA, UnitedStates, March 28-April 1, 2004 (2004).$dZ+B?Di7c2Z0V F
Lee, Seung-Wuk;Belcher, Angela M.. Virus-Based Fabrication of Micro- and NanofibersUsing Electrospinning. Nano Letters (2004), 4(3), 387-390.
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Ni,Jingping; Lee, Seung-Wuk; White, John M.; Belcher, Angela M.. Molecularorientation of a ZnS-nanocrystal-modified M13 virus on a siliconsubstrate. Journal of Polymer Science, Part B: Polymer Physics (2004),42(4), 629-635. q4O-@| p'[ rR1a
Mao, Chuanbin; Solis, Daniel J.; Reiss,Brian D.; Kottmann, Stephen T.; Sweeney, Rozamond Y.; Hayhurst, Andrew;Georgiou, George; Iverson, Brent; Belcher, Angela M.. Virus-basedtoolkit for the directed synthesis of magnetic and semiconductingnanowires. Science (Washington, DC, United States) (2004), 303(5655),213-217.
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Nam, Ki Tae; Peelle, Beau R.; Lee, Seung-Wuk;Belcher, Angela M.. Genetically Driven Assembly of Nanorings Based onthe M13 Virus. Nano Letters (2004), 4(1), 23-27. yb9jl h!jGg
Flynn,Christine E.; Lee, Seung-Wuk; Peelle, Beau R.; Belcher, Angela M..Viruses as vehicles for growth, organization and assembly of materials.Acta Materialia (2003), 51(19), 5867-5880.
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Qi, Jifa; Mao,Chuanbin; White, John M.; Belcher, Angela M.. Optical anisotropy inindividual CdS quantum dot ensembles. Physical Review B: CondensedMatter and Materials Physics (2003), 68(12), 125319/1-125319/6.
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Flynn,Christine E.; Mao, Chuanbin; Hayhurst, Andrew; Williams, Julie L.;Georgiou, George; Iverson, Brent; Belcher, Angela M.. Synthesis andorganization of nanoscale II-VI semiconductor materials using evolvedpeptide specificity and viral capsid assembly. Journal of MaterialsChemistry (2003), 13(10), 2414-2421. {5MWOc(BL5M F"T
Mao, Chuanbin; Qi,Jifa; Belcher, Angela M.. Building Quantum Dots into solids withwell-defined shapes. Advanced Functional Materials (2003), 13(8),648-656.
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Mao, Chuanbin; Flynn, Christine E.; Hayhurst,Andrew; Sweeney, Rozamond; Qi, Jifa; Georgiou, George; Iverson, Brent;Belcher, Angela M.. Viral assembly of oriented quantum dot nanowires.Proceedings of the National Academy of Sciences of the United States ofAmerica (2003), 100(12), 6946-6951. _7d!hM5h*W9`']Z
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Lee, Seung-Wuk; Lee,Soo Kwan; Belcher, Angela M.. Virus-based alignment of inorganic,organic, and biological nanosized materials. Advanced Materials(Weinheim, Germany) (2003), 15(9), 689-692.K ]x e#_yp~ i
Lee, S.W., B.M. Wood and A.M. Belcher, “Chiral Smectic C* Structures of Viral Films,” Langmuir 19, 1592-1598 (cover), 2003.
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Qi,Jifa; White, John M.; Belcher, Angela M.; Masumoto, Yasuaki. Opticalspectroscopy of silicon nanowires. Chemical Physics Letters (2003),372(5,6), 763-766.
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Qi, Jifa; Belcher, Angela M.; White,John M. Spectroscopy of individual silicon nanowires. Applied PhysicsLetters (2003), 82(16), 2616-2618. 1sN~e:fP;bK-a
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Su, Xiaowei; Belcher,Angela M.; Zaremba, Charlotte M.; Morse, Daniel E.; Stucky, Galen D.;Heuer, Arthur H. Structural and microstructural characterization of thegrowth lines and prismatic microarchitecture in red abalone shell andthe microstructures of abalone "flat pearls". Chemistry of Materials(2002), 14(7), 3106-3117.
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Seeman, Nadrian C.; Belcher,Angela M.. Emulating biology: building nanostructures from the bottomup. Proceedings of the National Academy of Sciences of the UnitedStates of America (2002), 99(9, Suppl. 2), 6451-6455. ?_k(Bk
Lee,Seung-Wuk; Mao, Chuanbin; Flynn, Christine E.; Belcher, Angela M..Ordering of quantum dots using genetically engineered viruses. Science(Washington, DC, United States) (2002), 296(5569), 892-895.
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Belcher,Angela M.; Gooch, Erin E. Protein components and inorganic structure inshell nacre. Biomineralization (2000), 221-249.
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Whaley,Sandra R.; Belcher, Angela M.. Borrowing ideas from nature:peptide-specific binding to gallium arsenide. Materials ResearchSociety Symposium Proceedings (2000), 599(Mineralization in Natural andSynthetic Biomaterials), 189-199.
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Whaley, Sandra R.;English, D. S.; Hu, Evelyn L.; Barbara, Paul F.; Belcher, Angela M..Selection of peptides with semiconductor binding specificity fordirected nanocrystal assembly. Nature (London) (2000), 405(6787),665-668.Y8Ic+p(_#\5s
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